Sunday, 4 May 2014

In it Together

The microbiome and the hosts have co-evolved together, creating a symbiotic relationship between them. However, there have been links created between the microbiome and carcinogenesis (Schwabe, R.F. & Jobin, C. 201). Carcinogenesis is triggered by a specific bacterial pathogens infection (Schwabe, R.F. & Jobin, C. 201). Gastric cancer for example is driven by H. pylori. Gastric cancer occurs in 1-3% of chronically infected individuals (Schwabe, R.F. & Jobin, C. 201). However, the presence of H. pylori, lowers the risk of esophageal adenocarcinoma (which is cancer of the esophagus)(Schwabe, R.F. & Jobin, C. 201).

Figure 1: Gastric cancer prevents food from entering the duodenum.

Figure 2: Esophageal adenocarcinoma can cause breathing and swallowing issues.

Aswell as infection, the imbalance of the microbiome can lead to carcinogenesis (Schwabe, R.F. & Jobin, C. 201). Liver and pancreatic cancer can be caused by the imbalance of the microbiome in the intestine (Schwabe, R.F. & Jobin, C. 201). An imbalance in the microbiome



Image References:
Figure 1: http://www.gastric-cancer.site40.net/images/sc.jpg by Anonymous retrieved on the 3/05/14
Figure 2: http://dxline.info/img/new_ail/esophageal-cancer_1.jpg by Anonymous, retrieved on the 4/05/14

Journal articles:
Schwabe, R.F. & Jobin, C. 2013, "The microbiome and cancer", Nature reviews, Cancer, vol. 13, no. 11, pp.800.

2 comments:

  1. I had no idea that bacteria could cause cancer. Do medical professionals worry about the bacteria causing cancer, or is it mostly just the infection they are concerned about?

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  2. Sorry I’m a bit confused …are you saying that our microbiomes may sometimes turn against and cause cancer, but that this is a trade-off because the bacterium that can cause gastric cancer helps prevent oesophageal cancer? If so, does this mean that the incidence of oesophageal cancer is much higher than gastric cancer, which could be why we rely on this bacterium?

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